ea0089b16 | Basic Science | NANETS2022
Schultz Michael K.
, Liu Dijie
, Li Mengshi
, Cagle Brianna S.
, Dai Zhiming
, Lee Dongyoul
, Orcutt Kelly
, Sagastume Edwin
, Baumhover Nicholas J.
, Vance Ivy
, Hedt Amos
, Menda Yusuf
, Johnson Frances L.
Background: Peptide-based targeted alpha-particle radiotherapy has emerged as a promising approach to cancer treatment. 203Pb/212Pb is the only elementally identical isotope pair for this application. Tyr3-Octreotide (TOC) peptide ligands targeting SSTR2 have been widely investigated preclinically and clinically. [177Lu]DOTATATE was approved by the US FDA to treat patients with gastroenteropancreatic neuroendocrine tumors. However, t...